| 产品描述： | Lercanidipine is a calcium channel blocker of the dihydropyridine class. |
| 靶点： |
Calcium Channel;CalciumChannel |
| 体内研究： |
In chronically catheterised dogs with experimental renovascular hypertension, lercanidipine decreases diastolic blood pressure in a dose-dependent manner (ED25 = 0.9 mg/kg p.o). In the same animals, long term application of lercanidipine showed permanent decrease of diastolic blood pressure indicating no tolerance of the antihypertensive effect. Lercanidipine possesses significant anticonvulsant effect. It does not affect the muscle coordination or locomotor activity in mice[5]. In clinical studies, lercanidipine has a 24-hour antihypertensive effect and causes no significant increase in heart rate. Lercanidipine has been shown to be effective in a wide range of hypertensive patients, including mild-to-moderate hypertension, severe hypertension, the elderly, and those with isolated systolic hypertension. It is associated with a low rate of adverse events |
| 细胞实验： |
Cells are incubated for 24 hours in DMEM+EFAF 0.2% and lercanidipine, then with lercanidipine and AcLDL for 24 hours. In the last 2 hours [14C]-oleic acid albumin complex is added for the determination of cholesterol esterification (ACAT activity). (Only for Reference) |
| 参考文献： |
1.Shereen M. Tawakkol, et al. Analytical Chemistry Letters. 2014, 4:255-266. 2.Epstein M, et al. Heart Dis. 2001, 3(6):398-407. 3.Selvaraj N, et al. J Clin Diagn Res. 2015, 9(11):FF01-5. 4.Gasser R, et al. Journal of Clinical and Basic Cardiology. 1999, 2(2):169-174. 5.Canavesi M, et al. J Cardiovasc Pharmacol. 2004, 44(4):416-422. |
| 溶解性： |
DMSO:64.8 mg/mL (100 mM) Ethanol:6.5 mg/mL (10 mM) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.522 ml |
7.608 ml |
15.216 ml |
| 5 mM |
0.304 ml |
1.522 ml |
3.043 ml |
| 10 mM |
0.152 ml |
0.761 ml |
1.522 ml |
| 50 mM |
0.03 ml |
0.152 ml |
0.304 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京