| 产品描述： | Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. |
| 靶点： |
Topoisomerase;Daunorubicins/Doxorubicins;Topoisomerase |
| 体内研究： |
Daun02 is a good substrate for β-gal with Km and Vmax values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin |
| 参考文献： |
1. Koya E, et al. Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. Nat Neurosci. 2009 Aug;12(8):1069-73. 2. Lehmann M, et al. Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila Somatic Mutation and Recombination Test. Environ Mol Mutagen. 2004;43(4):250-7. 3. Farquhar D, et al. Suicide gene therapy using E. coli beta-galactosidase.Cancer Chemother Pharmacol. Cancer Chemother Pharmacol. 2002 Jul;50(1):65-70. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.13 ml |
5.651 ml |
11.302 ml |
| 5 mM |
0.226 ml |
1.13 ml |
2.26 ml |
| 10 mM |
0.113 ml |
0.565 ml |
1.13 ml |
| 50 mM |
0.023 ml |
0.113 ml |
0.226 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京