| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
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| 源叶(MedMol) | S86952-5mg | 98% | ￥425.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S86952-10mg | 98% | ￥720.00元 | 7 | - | - | - |
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| 源叶(MedMol) | S86952-25mg | 98% | ￥1230.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S86952-50mg | 98% | ￥2450.00元 | 5 | - | - | - |
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| 产品描述： Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma | ||||||||||||||||||||
| 靶点： DP2:1.14 nM (Kd);GPR;ProstaglandinReceptor | ||||||||||||||||||||
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体外研究： Fevipiprant (0-10 µM) inhibits the gene expression of IL-4, IL-3, IL-5, IL-8, CSF1, CSF2 in n in human Th2 cells induced by activated mast cell supernatants |
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体内研究： Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse. Animal Model: C57Bl/6 mice Dosage: 10 mg/kg Administration: In the drinking water Result: Efficiently reduced CaCl2-induced AAA formation with diminished elastin degradation, aortic macrophage infiltration, MPO accumulation and MCP-1 expression. |
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参考文献： 1. Brightling C, et al. The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant. Pulm Pharmacol Ther. 2021 Jun;68:102030. 2. Lee HY, et al. Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma. Korean J Intern Med. 2020 May;35(3):619-629. 3. Weintraub NL, et al. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Clin Sci (Lond). 2022 Mar 18;136(5):309-321. |
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| 溶解性： soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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