货号	规格	价格	上海	北京	珠海	重庆	武汉
S88179-5mg买3赠1	99.30%	￥220.00 S88179-5mg ￥220.00 现货（买3赠1）	4 6 4	4	2	-	-
S88179-10mg买3赠1	99.30%	￥360.00 S88179-10mg ￥360.00 现货（买3赠1）	6 6	-	-	-	-
S88179-25mg买3赠1	99.30%	￥750.00 S88179-25mg ￥750.00 现货（买3赠1）	1 1	-	-	-	-
S88179-50mg买3赠1	99.30%	￥1270.00 S88179-50mg ￥1270.00 现货（买3赠1）	4 4	-	-	-	-
S88179-100mg买3赠1	99.30%	￥2400.00 S88179-100mg ￥2400.00 现货（买3赠1）	3 3	-	-	-	-

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产品描述：

Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux

靶点：

NMDA Receptor;NMDAR; iGluR

体内研究：

Dizocilpine (MK 801) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice. Dizocilpine ((+)-MK 801) (0.05, 0.2 mg/kg, i.p.) attenuates subsequent cocaine-primed reinstatement without disruption in rats. Dizocilpine (MK 801) (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage shows no suppression on subsequent cocaine-primed reinstatement

参考文献：

1. Wong EH, et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. 2. Vardhan Reddy KH, et al. Convergent Strategy to Dizocilpine MK-801 and Derivatives. J Org Chem. 2018 Apr 6;83(7):4264-4269. 3. Huettner JE, et al. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb;85(4):1307-11. 4. Thomas DM, et al. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Res. 2005 Jul 19;1050(1-2):190-8. 5. Brown TE, et al. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008 Dec 2;15(12):857-65.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.519 ml	22.594 ml	45.188 ml
5 mM	0.904 ml	4.519 ml	9.038 ml
10 mM	0.452 ml	2.259 ml	4.519 ml
50 mM	0.09 ml	0.452 ml	0.904 ml