6-羟基多巴胺盐酸盐;2,4,5-三羟基苯乙胺盐酸盐;2,5-二羟基酪胺盐酸盐;6-羟基多巴胺盐酸盐;盐酸-2,4,5-三羟基苯乙胺;盐酸-6-羟基多巴胺;6-羟基多巴胺(H4381);6-羟基多巴胺合氯化氢;5-(2-氨基乙基)-1,2,4-苯三酚盐酸盐;6-Ohda;6-Hydroxydopamine Hydrochloride;2,4,5-Trihydroxyphenethylamine H
Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome
产品描述：
Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome
靶点：
COX-2;IL-1β;Caspase-3;Caspase-8;Caspase-9
体内研究：
Oxidopamine hydrochloride (5 µg/2 µL, unilaterally injected into the right striatum) induces degeneration of dopaminergic neurons in substantia nigra of rats
参考文献：
1. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. 2. Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82. 3. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. 4. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京