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  1. 首页 > 标准品 > 中药标准品 > 甾体及甾体皂苷类 > 葫芦素B

葫芦素B

    
分析标准品,HPLC≥97%

Cucurbitacin B

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源叶
B20523 一键复制产品信息
6199-67-3
C32H46O8
558.71
MFCD07778083
Cucurbitacin B
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
B20523-5mg
 分析标准品,HPLC≥97%

￥200.00

 7 - - - -
B20523-20mg
 分析标准品,HPLC≥97%

￥450.00

 >10 >10 5 - 2
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产品介绍 参考文献(31篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

SMILES： O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O
熔点： 184-186°C
沸点： 699.3°C at 760 mmHg
比旋光度： D25 +88° (c = 1.55 in ethanol)
外观： 白色晶体
溶解性： 易溶于氯仿
储存条件： 2-8℃
密度： 1.23
注意： 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(31篇)

31. [IF=2.8] Yang Wang, et al. "Rapid Identification of Chemical Components and Screening of Beta–Klotho Agonists From Trichosanthes pericarpium Aqueous Extract Based on Affinity Ultrafiltration and Liquid Chromatography–Tandem Mass Spectrometry"JOURNAL OF SEPARATION 30. [IF=3] Huizhong Zhang et al."Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway."CURRENT ISSUES IN MOLECULAR BIOLOGY.2026 Jan;48(2):138 29. [IF=13.2] Yujiao Jia et al."Application of nano-selenium and glutathione with pyrimethanil enhance cucumber resistance to Botrytis cinerea by boosting root secretion and recruiting beneficial microorganisms."CHEMICAL ENGINEERING JOURNAL.2025 Dec;:172174 28. [IF=4.8] Chun-nan Zhang et al."Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS."Frontiers in Pharmacology.2025 Sep;16: 27. [IF=5] Dongge Yin et al."Cucurbitacin B from Cucurbitaceae Plants: Treating Pancreatic Cancer via Inducing Mitophagy, Inhibiting Glycolysis, and Enhancing Immune Function."Nutrients.2025 Jan;17(17):2809
26. [IF=5] Dongge Yin et al."Cucurbitacin B from Cucurbitaceae Plants: Treating Pancreatic Cancer via Inducing Mitophagy, Inhibiting Glycolysis, and Enhancing Immune Function."Nutrients.2025 Jan;17(17):2809 25. [IF=5.4] Xiao-yu Zhang et al."Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation."JOURNAL OF E 24. [IF=1.8] Haiqiang Wang et al."Simultaneous determination of four phytoecdysteroids by LC-MS/MS: application to a comparative pharmacokinetic study in normal and adjuvant arthritis rats after oral administration of C. officinalis Kuan phytoecdysteroids extract."XENO 23. [IF=5.895] Qi Wang et al."Discovery and Identification of the Key Contributor to the Bitter Taste in Oriental Melon after Forchlorfenuron Application."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX 22. [IF=5.988] Zhang Xin et al."Integrating pharmacological evaluation and computational identification for deciphering the action mechanism of Yunpi-Huoxue-Sanjie formula alleviates diabetic cardiomyopathy."Frontiers in Pharmacology.2022 Sep;0:3551 21. [IF=3.391] Jiaxin Xu et al."Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity."Arch Biochem Biophys. 2020 May;684:108314 20. [IF=1.98] Yanting Chai et al."Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells."Med Sci Monitor. 2018; 24: 9251–9258 19. [IF=2.439] Wenjing Ma et al."Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia."J Pharmacol Sci. 2019 Apr;139:304 18. [IF=3.205] Zhibin Wang et al."Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets."J Chromatogr B. 2017 Oct;1065-1066:63 17. [IF=3.267] Pengfei Liu et al."Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer."Molecules. 2019 Jan;24(3):647 16. [IF=3.417] Fen Cai et al."Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells."Oncol Rep. 2016 Aug;36(2):1180-1186 15. [IF=4.784] Shanshan Qin et al."Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme."Mol Carcinogen. 2018 Jun;57(6):687-699 14. Liu, Xuewen, et al. "Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells." Oncology reports 38.1 (2017): 271-278.https://doi.org/10.3892/or.2017.5648 13. Qin, Shanshan, et al. "Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme." Molecular carcinogenesis 57.6 (2018): 687-699. 12. Ma, Wenjing, et al. "Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t (8; 21) acute myeloid leukemia." Journal of pharmacological sciences 139.4 (2019): 304-310.https://doi.org/10.1016/j.jphs.2018.12.010 11. Liu, Pengfei, et al. "Cucurbitacin B induces the lysosomal degradation of EGFR and suppresses the CIP2A/PP2A/Akt signaling Axis in Gefitinib-resistant non-small cell lung Cancer." Molecules 24.3 (2019): 647.647; https://doi.org/10.3390/molecules24030647 10. Xu, Jiaxin, et al. "Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity." Archives of biochemistry and biophysics 684 (2020): 108314.https://doi.org/10.1016/j.abb.2020.108314 9. Chai, Yanting, et al. "Cucurbitacin B inhibits the Hippo-YAP signaling pathway and exerts anticancer activity in colorectal cancer cells." Medical science monitor: international medical journal of experimental and clinical research 24 (2018): 9251.10.12659 8. Cai, Fen, et al. "Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells." Oncology reports 36.2 (2016): 1180-1186.https://doi.org/10.3892/or.2016.4892 7. 张雅男 高明洁 祝文博 等. HPLC-UV法同时测定葫芦素片中葫芦素B和葫芦素E的含量[J]. 化学工程师 2018. 6. 周彤,杨书胜,罗明洲,向可,刘莹,陈森.葫芦素B通过抑制Hippo-YAP通路抑制结肠癌细胞转移的机制研究[J].湖北医药学院学报,2020,39(01):16-21+2+105. 5. 陈芳, 沈成英, 申宝德,等. 葫芦素B纳米混悬凝胶剂的制备及其体外透皮研究[J]. 解放军药学学报, 2015(1):49-52. 4. 胡瑞瑞, 张家梁, 郝海军. 葫芦素B磷脂复合物纳米结构脂质载体的制备[J]. 中成药, 2019, v.41(11):25-30. 3. 万露, 肖云芝, 程玲,等. 葫芦素B磷脂复合物制备,表征及体外抗肿瘤活性研究. 中草药. 2. 季娟丽,张云飞,司渊,刘鹏飞,钦闪闪,刘莹.葫芦素B抑制人顺铂耐药胃癌细胞的作用及机制研究[J].湖北医药学院学报,2017,36(05):386-390+403+374. 1. 程玲, 申宝德, 李娟娟,等. 外翻肠囊法研究葫芦素B胆盐磷脂混合胶束大鼠肠吸收动力学[J]. 中国中药杂志, 2015, 40(014):2876-2881.

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