辛伐他汀

    
分析标准品,HPLC≥97.5%

Simvastatin

源叶
B21384 一键复制产品信息
79902-63-9
C25H38O5
418.57
MFCD00072007
货号 规格 价格 上海 北京 武汉 南京 购买数量
B21384-20mg 分析标准品,HPLC≥97.5% ¥150.00 >10 1 - 1
B21384-100mg 分析标准品,HPLC≥97.5% ¥450.00 货期:2-3天 - - -
B21384-200mg 分析标准品,HPLC≥97.5% ¥600.00 货期:2-3天 - - -
产品介绍 参考文献(19篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Simvastatin (MK 77333) 是一种具有口服活性的 HMG-CoA 还原酶 (HMGCR) 竞争性抑制剂, Ki 为 0.2 nM。Simvastatin 可减少胆固醇的合成,降低血液中的胆固醇水平。Simvastatin 对癌细胞表现出抗增殖活性,并能诱导细胞凋亡 (apoptosis)。

熔点: 139°C
沸点: 564.9 °C at 760 mmHg
比旋光度: D25 +292° (c = 0.5% in acetonitrile)
外观: 白色结晶性粉末
溶解性: Ethanol  :  100  mg/mL  (238.91  mM;  Need  ultrasonic)

DMSO  :  ≥  50  mg/mL  (119.45  mM)
敏感性: 对湿度和空气敏感
储存条件: -20℃
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(19篇)

14. [IF=7] Zhuoya Xiang et al."Purification of Phenolic Compounds from Camellia polyodonta Flower: Composition Analysis, Antioxidant Property, and Hypolipidemic Activity In Vitro and In Vivo."Antioxidants".2024 Jun;13(6):662 13. [IF=5.4] Yingkun Sheng et al."Dan-shen Yin promotes bile acid metabolism and excretion to prevent atherosclerosis via activating FXR/BSEP signaling pathway."JOURNAL OF ETHNOPHARMACOLOGY".2024 Apr;:118209 12. [IF=2.1] He Ying et al."Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice."BMC Cardiovascular Disorders".2024 Dec;24(1):1-11 11. [IF=5.318] Ge Xu et al."Non-targeted cellular metabolomics revealing the metabolomic features and anti-tumor mechanisms of cyanidin-3-O-arabinoside on Caco-2 cells."Food Bioscience.2023 Feb;51:102296 10. [IF=9.231] Yue Xiao et al."Insight into structural characteristics of theabrownin from Pingwu Fuzhuan brick tea and its hypolipidemic activity based on the in vivo zebrafish and in vitro lipid digestion and absorption models."FOOD CHEMISTRY.2022 Sep;:134382 9. [IF=5.589] Jinfeng Chen et al."Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms."EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS.2022 Sep;178:82 8. [IF=4.24] Dan Zhang et al."Assessment of the anti-tumor activity of cyanidin-3-O-arabinoside from apple against APN, JAK, and EZH2 target proteins."Food Bioscience. 2022 May;:101788 7. [IF=4.33] Le Gu et al."Study on chemical constituents of Folium Artemisiae argyi Carbonisatum, toxicity evaluation on zebrafish and intestinal hemostasis."Saudi Pharm J. 2022 Mar;: 6. [IF=2.1] Yuyan Zhang et al."Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression."Mol Med Rep. 2021 Jan;23(1):1-1 5. [IF=3.24] Bingli Zhao et al."Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice."Plos One. 2019 Jun;14(6):e0218543 4. [IF=11.161] Feng Jiao et al."Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis."J Exp Clin Canc Res. 2020 Dec;39(1):1-18 3. [IF=2.69] Xiaowei Yuan et al."Using co-axial electrospray deposition to eliminate burst release of simvastatin from microparticles and to enhance induced osteogenesis."J Biomat Sci-Polym E. 2019;30(5):355-375 2. [IF=8.456] Hongfei Qi et al."Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair."Acs Appl Mater Inter. 2019;11(8):8625–8634 1. 张月晓,李萍,李炳庆,陈健.辛伐他汀通过NF-κB p65通路影响食管癌细胞增殖[J].中国病理生理杂志,2020,36(09):1690-1695.

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