源叶
B27248
一键复制产品信息
144060-53-7
C16H16N2O3S
316.37
MFCD00871598
2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸;2-[3-Cyano-4-Isobutoxyphenyl]-4-Methylthiazole-5-Carboxylic Acid;2-[3-Cyano-4-(2-Methylpropoxy)Phenyl]-4-Methyl-1,3-Thiazole-5-Carboxylic Acid
非布索坦 分析标准品,HPLC≥98%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
B27248-20mg |
分析标准品,HPLC≥98% | ￥100.00 |
>10 | - | - | - | - |
|
B27248-500mg |
分析标准品,HPLC≥98% | ￥1500.00 |
7 | - | - | - | - |
|
产品介绍
Febuxostat 是一种选择性黄嘌呤氧化酶(XO)抑制剂，Ki=0.6 nM。
| SMILES： | O=C(C1=C(C)N=C(C2=CC=C(OCC(C)C)C(C#N)=C2)S1)O |
|---|---|
| 熔点： | 238-239°C |
| 沸点： | 536.6°C at 760 mmHg |
| 外观： | 结晶固体 |
| 溶解性： | DMSO:23.7 mg/mL (75 mM) Ethanol:15.8 mg/mL (50 mM) |
| 储存条件： | RT |
| 密度： | 1.31 |
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(13篇)
13. [IF=6.3] Lieqiang Xu et al."Protective Effects of Oxyberberine Against Hyperuricemic Nephropathy: Mechanistic Insights From In Silico, In Vitro, and In Vivo Studies."PHYTOTHERAPY RESEARCH.2026 Jan;:
12. [IF=4] Gaoxiang Ai et al."Unveiling the sweet culprit: Excessive fructose intake leading to kidney injury through hypoxanthine accumulation."Journal of Functional Foods.2025 Aug;131:106959
11. [IF=4.8] Xiaoyan Wu et al."9-Hydroxy-8-oxypalmatine, a novel liver-mediated oxymetabolite of palmatine, alleviates hyperuricemia and kidney inflammation in hyperuricemic mice."JOURNAL OF ETHNOPHARMACOLOGY.2024 Dec;335:118606
10. [IF=4.8] Shiting Gong et al."Kidney targeting and modulating macrophage polarization through AMPK signaling: Therapeutic mechanism of berberine in uric acid nephropathy."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Sep;138:112632
9. [IF=4.9] Huiyan Sun et al."Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy."Pharmaceutics.2024 Jul;16(7):938
8. [IF=6.6] Ziwei Huang et al."Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application."International Journal of Nanomedicine.
7. [IF=5.581] Zhi-Xu Zhang et al."Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production."Metabolites.2023 Jun;13(6):704
6. [IF=7.419] Yanlu Liu et al."Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway."BIOMEDICINE & PHARMACOTHERAPY.2022 Dec;156:113941
5. [IF=5.195] Gaoxiang Ai et al."Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jan;301:115775
4. [IF=6.656] Linjiang Zhong et al."Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice."PHYTOMEDICINE.2023 Jan;108:154521
3. [IF=5.81] Xu Lieqiang et al."Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice."Front Pharmacol. 2021 Apr;0:804
2. [IF=6.529] Haiyang Yang et al."Accurate quantitative determination of affinity and binding kinetics for tight binding inhibition of xanthine oxidase."Biomed Pharmacother. 2021 Jul;139:111664
1. Xu, Lieqiang, et al. "Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate-and Hypoxanthine-Induced Hyperuricemic Mice." Frontiers in Pharmacology 12 (2021): 804.
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)