铁调素-25（人），三氟乙酸盐

产品介绍

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. 

铁调素-25 是铁调素的主要同种型。 铁调素-25 中的网织红细胞血红蛋白含量 (CHr) 有助于鉴别 DA 可将缺铁性贫血 (IDA) 与慢性病贫血 (ACD) 及 ACD/IDA 合并状态相鉴别。铁调素基因突变与严重青少年血色病的发生有关。
铁调素是铁稳态的主要调节因子。铁调素存在于肝脏中，但也广泛分布于脑中，可能在预防铁相关的神经退行性病变中发挥作用。铁调素具有抗炎和抗菌活性。
铁调素是铁稳态的主要调节因子，具有抗炎和抗菌活性。
序列：Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bridge:Cys7-Cys23; Cys10-Cys13; Cys11-Cys19; Cys14-Cys22)