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IgD于1965年首次被发现，与其他免疫球蛋白一样，它以分泌和膜的形式存在。IgD在血浆中的水平较低，平均浓度为30ug/ml。IgD大量存在于大多数人循环B淋巴细胞的表面膜上。IgD通过诱导T淋巴细胞上IgD受体的表达来增强体液免疫反应。由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。 Ref:Coico RF, Siskind GW, Thorbecke GJ 1988. Immunol. Rev. 105:45.;IgD was first identified in 1965, and like other immunoglobulins, exists as both secreted and membrane forms. Its level in plasma is low with a mean concentration of 30 ug/ml. IgD is present in large quantities on the surface membrane of a majority of human circulating B lymphocytes. IgD enhances humoral immune responses through its induction of IgD-receptor expression on T lymphocytes.Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.Ref:Coico RF, Siskind GW, Thorbecke GJ 1988. Immunol. Rev. 105:45.