产品描述: | Polymyxin B nonapeptide TFA 是一种阳离子环肽。Polymyxin B nonapeptide TFA 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide TFA 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。 |
体外研究: |
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS). |
参考文献: |
1. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92. 2. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
0.652 ml |
3.261 ml |
6.522 ml |
5 mM |
0.13 ml |
0.652 ml |
1.304 ml |
10 mM |
0.065 ml |
0.326 ml |
0.652 ml |
50 mM |
0.013 ml |
0.065 ml |
0.13 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |