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产品描述： CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM |
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靶点：
IC50: 0.5 nM (CSF1R);c-Fms |
体内研究：
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept. |
参考文献：
1. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. |
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溶解性：
DMSO : 83.33 mg/mL (173.80 mM; Need ultrasonic) |
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保存条件：
-20℃ |
配置溶液浓度参考：
|
1mg |
5mg |
10mg |
| 1 mM |
2.086 ml |
10.429 ml |
20.857 ml |
| 5 mM |
0.417 ml |
2.086 ml |
4.171 ml |
| 10 mM |
0.209 ml |
1.043 ml |
2.086 ml |
| 50 mM |
0.042 ml |
0.209 ml |
0.417 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京