| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S23323-1mg | 98% | ￥245.00元 | 8 | - | - | - |
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| 源叶(MedMol) | S23323-5mg | 98% | ￥750.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S23323-10mg | 98% | ￥1250.00元 | 6 | - | - | - |
|
| 源叶(MedMol) | S23323-25mg | 98% | ￥2240.00元 | 6 | - | - | - |
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ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease
| 产品描述： | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease | ||||||||||||||||||||
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| 靶点： | EC50: 0.4 μM (glucocerebrosidase);Glucokinase | ||||||||||||||||||||
| 体外研究： | ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr. ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts. ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility. |
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| 参考文献： | 1. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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