货号	规格	价格	上海	北京	珠海	重庆	武汉
S23408-1mg买3赠1	99.80%	￥80.00 S23408-1mg ￥80.00 现货（买3赠1）	9 9	-	-	-	-
S23408-5mg买3赠1	99.80%	￥110.00 S23408-5mg ￥110.00 现货（买3赠1）	7 7	-	-	-	-
S23408-10mg买3赠1	99.80%	￥200.00 S23408-10mg ￥200.00 现货（买3赠1）	7 7	-	-	-	-
S23408-25mg买3赠1	99.80%	￥400.00 S23408-25mg ￥400.00 现货（买3赠1）	7 7	-	-	-	-
S23408-100mg促销	99.80%	￥1060.00 ￥848.00 S23408-100mg ￥848.00 现货	6 6	-	-	-	-

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产品描述：

MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake

靶点：

IGF-1R

体外研究：

MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.

MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.

MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.

MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.

MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.

MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.

体内研究：

MID-1 does not have good pharmacokinetics in vivo.

参考文献：

1. Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.409 ml	17.047 ml	34.095 ml
5 mM	0.682 ml	3.409 ml	6.819 ml
10 mM	0.341 ml	1.705 ml	3.409 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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