| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S23417-5mg促销 |
≥98%(HPLC) | ￥200.00 ￥180.00 |
6 | - | - | - | - |
|
S23417-10mg促销 |
≥98%(HPLC) | ￥310.00 ￥279.00 |
5 | - | - | - | - |
|
S23417-25mg促销 |
≥98%(HPLC) | ￥479.00 ￥430.00 |
2 | - | - | - | - |
|
S23417-50mg促销 |
≥98%(HPLC) | ￥716.00 ￥645.00 |
1 | - | - | - | - |
|
S23417-100mg促销 |
≥98%(HPLC) | ￥1290.00 ￥1160.00 |
2 | - | - | - | - |
|
| 产品描述： | KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity |
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| 靶点： | MBD2 (methyl-CpG-binding domain protein 2);DNAAlkylator/Crosslinker | ||||||||||||||||||||
| 体外研究： | KCC-07 (10 μM; 72 hours; MB cells) treatment clearly inhibited MB cell growth in vitro, consistent with induction of anti-proliferative BAI1/p53/p21 signaling. KCC-07 (10 μM; 48 hours; MB cells) treatment largely abrogates MBD2 binding to the ADGRB1 promoter and restores BAI1 mRNA and protein expression in BAI1-silent MB cells. |
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| 体内研究： | KCC-07 (100 mg/kg; intraperitoneal injection; 5 days/week; athymic nude mice) treatment inhibits tumor growth and significantly extends the survival of MB xenografts in vivo. Animal Model: Outbred athymic nude mice (females; 8-10 weeks old) injected with MB cells Dosage: 100 mg/kg Administration: Intraperitoneal injection; 5 days/weekResult: Significantly extended the survival of MB xenografts in vivo. | ||||||||||||||||||||
| 参考文献： | 1. Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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