鬼臼毒素 98%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S24887-1g |
98% | ￥38.00 |
3 | 1 | - | - | - |
|
S24887-5g |
98% | ￥148.00 |
3 | - | - | - | - |
|
S24887-25g |
98% | ￥578.00 |
6 | - | - | - | - |
|
产品介绍
Podofilox (Podophyllotoxin) 是微管组装和DNA拓扑异构酶II抑制剂。
| SMILES： | O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@]21[H] |
|---|---|
| 熔点： | 183-184°C(lit.) |
| 沸点： | 597.9°C at 760 mmHg |
| 比旋光度： | -110.7 o (C=1, CHCL3) |
| 外观： | 白色针状结晶粉末 |
| 溶解性： | DMSO : 100 mg/mL (241.31 mM; Need ultrasonic) |
| 储存条件： | 2-8℃ |
| 密度： | 1.37 |
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(16篇)
16. [IF=3.1] Yuanyang Shao, et al. "Podophyllotoxin induces testicular toxicity via the microbiota-gut-testis axis based on the toxicological evidence chain concept"JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2026 Nov;264:107092
15. [IF=4.2] Ru Yi, et al. "Role of gut microbiota dysbiosis in podophyllotoxin-induced neurotoxicity in zebrafish: linking purine metabolism to synaptic dysfunction"BMC MICROBIOLOGY, 2026 Apr;:
14. [IF=2.6] Guo Xiaole, et al. "An integrated multi-omics approach for deciphering podophyllotoxin-induced nephrotoxicity via the microbiome-gut-kidney (MGK) axis based on the toxicological evidence (TEC) concept"JOURNAL OF MOLECULAR HISTOLOGY, 2026 Jun;57(3):176
13. [IF=3.6] Tao Jiang, et al. "Regionally specific dysregulation of gut microbiota and host–metabolite interface in podophyllotoxin-induced enterotoxicity based on the toxicological evidence chain concept"TOXICOLOGY AND APPLIED PHARMACOLOGY, 2026 Jul;512:117862
12. [IF=4.7] Yanzhao Zhang et al."Podophyllotoxin-induced acute kidney injury via the HMGB1/TLR4/MyD88/NF-κB axis in SD rats based on the toxicological evidence chain (TEC) concept via multiomic analysis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Dec;166:115530
11. [IF=5.4] Chuanxin Liu et al."Investigating Podophyllotoxin-Induced Cardiotoxicity in Rats by Toxicological Evidence Chain (TEC): Focus on the Akt1/Srebp-1c/PUFAs Axis."CHEMICO-BIOLOGICAL INTERACTIONS.2025 Jul;:111634
10. [IF=6.2] Chuanxin Liu et al."Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2025 Jan;289:1
9. [IF=6.2] Jingjing Li et al."Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2025 Jan;290:117617
8. [IF=6.2] Jiajia Duan et al."Exploring the mechanism of enterotoxicity mediated by the microbiome-butyrate-PPAR axis in podophyllotoxin through the toxicological evidence chain (TEC) concept."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Jul;280:116548
7. [IF=7.9] Tao Jiang et al."Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept."PHYTOMEDICINE".2024 Apr;:155655
6. [IF=6.291] Jiao Kong et al."Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept."Ecotox Environ Safe. 2022 Feb;231:113157
5. Zi, Cheng-Ting, et al. "Synthesis and Anticancer Activity of 4 β-Triazole-podophyllotoxin Glycosides." Natural products and bioprospecting 5.2 (2015): 83-90.
4. 范素芳, 马俊美, 刘茁,等. 高效液相色谱-串联质谱测定食品中15种有毒生物碱[J]. 食品科学, 2018, 39(22):290-295.
3. 董玉鹏 孙萍 李永才 毕阳 张苗 黄怡 张婷婷.反式-2-己烯醛对梨果黑斑病菌Alternaria alternata的抑菌作用及其机理[J].食品科学 2020 41(07):191-197.
2. 山金凤, 刘宁芝, 杜欣韵,等. 鬼臼甘草配伍有效成分提取工艺的研究[J]. 现代化工, 2016(12):47-50.
1. 王萍 陈涛 刘永玲 等. 响应面法优化桃儿七中鬼臼毒素的热回流提取工艺[J]. 中药材 2012 35(011):1864-1867.
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