货号	规格	价格	上海	北京	珠海	重庆	武汉
S29709-1mg买3赠1	99.08%	￥170.00 S29709-1mg ￥170.00 现货（买3赠1）	8 0 8	-	-	-	-
S29709-5mg买3赠1	99.08%	￥390.00 S29709-5mg ￥390.00 现货（买3赠1）	5 5	-	-	-	-
S29709-25mg买3赠1	99.08%	￥1090.00 S29709-25mg ￥1090.00 现货（买3赠1）	8 8	-	-	-	-

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产品描述：

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

靶点：

amyloid-β peptides;BetaAmyloid

体内研究：

The post hoc test indicates that the mean density of PSA-positive cells is significantly larger in the vehicle and Aβ infusion+high-dose Edonerpic maleate (T-817MA) groups than that in the Aβ infusion control group (P<0.01). The results indicate that the vehicle and Aβ infusion+high-dose Edonerpic maleate groups display efficient learning in the place learning task (PLT), while these two groups also display vigorous neurogenesis. Treatment with Edonerpic maleate and donepezil does not increase the mean density of normal granule cells; there are no significant differences in the mean granule cell density among the Aβ infusion control, Aβ infusion+high-dose Edonerpic maleate, Aβ infusion+low-dose Edonerpic maleate and Aβ infusion+donepezil groups

参考文献：

1. Hirata K, et al. A novel neurotrophic agent, T-817MA [1-{3-[2-(1-benzothiophen-5-yl) ethoxy] propyl}-3-azetidinol maleate], attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons. J Phar 2. Kimura T, et al. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide. Br J Pharmacol. 2009 Jun;157(3):451-63.

溶解性：

DMSO : 100 mg/mL (245.41 mM; Need ultrasonic) H2O : 100 mg/mL (245.41 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.454 ml	12.271 ml	24.541 ml
5 mM	0.491 ml	2.454 ml	4.908 ml
10 mM	0.245 ml	1.227 ml	2.454 ml
50 mM	0.049 ml	0.245 ml	0.491 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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