冈田酸
高纯，≥95%(HPLC)
Okadaic acid
冈田酸 高纯，≥95%(HPLC)
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S30686-25ug |
高纯，≥95%(HPLC) | ￥800.00 |
>10 | 2 | 1 | - | - |
|
S30686-50ug |
高纯，≥95%(HPLC) | ￥1330.00 |
>10 | - | 2 | - | - |
|
S30686-500ug |
高纯，≥95%(HPLC) | ￥7980.00 |
2 | - | - | - | - |
|
S30686-1mg |
高纯，≥95%(HPLC) | ￥12000.00 |
货期：2-3天 | - | - | - | - |
|
产品介绍
Okadaic acid 是一种海洋毒素，是蛋白质磷酸酶 (PP) 的抑制剂，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中对 PP2A 的亲和力最显著，但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
| SMILES： | C[C@H](CC1)[C@@]([H])([C@@H](C)C[C@H](O)[C@@]2([H])O[C@@](CC[C@@]3(CC[C@H](/C=C/[C@@H](C)[C@]4([H])CC(C)=C[C@@]5(O[C@H](C[C@](O)(C)C(O)=O)CC[C@H]5O)O4)O3)O6)([H])[C@]6([H])[C@H](O)C2=C)O[C@@]71OCCCC7 |
|---|---|
| 溶解性： | 25ug量少看不见，原本是溶液形式分装后进行冻干的，只能整瓶溶解，使用DMSO溶解，DMSO母液可以分装储存在4℃，尽快使用，细胞实验可以直接使用培养基稀释。 |
| 储存条件： | -20℃ |
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(23篇)
23. [IF=6.7] Shuping Shi, et al. "A Tb-metal-organic gel enhanced electrochemiluminescence biosensor with a supersandwich DNA walker for okadaic acid detection"TALANTA, 2026 Dec;310:130101
22. [IF=8.3] Lili Gu, et al. "Flavonoids of Ziziphora clinopodioides improve Alzheimer's cognitive impairment and inhibit NLRP3 inflammasome activation via autophagy-lysosome pathway"PHYTOMEDICINE, 2026 Mar;:158028
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16. [IF=6.1] Zhiqiang Luo et al."Integrating network toxicology, transcriptomics, and metabolomics uncovers the hepatotoxic mechanisms of okadaic acid in LO2 cells."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2025 Sep;302:118576
15. [IF=9.6] Hanbing Xu et al."Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease."Advanced Healthcare Materials.2025 May;:2500941
14. [IF=3] Hongce Song et al."Short-term exposure to okadaic acid induces behavioral and physiological responses in sea urchin (Strongylocentrotus intermedius)."MARINE ENVIRONMENTAL RESEARCH.2024 Nov;202:106823
13. [IF=3.5] Lei Li et al."The Improvement Effects of Sika Deer Antler Protein in an Alzheimer's Disease Mouse Model via the Microbe–Gut–Brain Axis."Food Science & Nutrition.2024 Dec;13(1):e4656
12. [IF=2.5] Juncheng Li et al."Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment."Neuropsychiatric Disease and Treatment.
11. [IF=2.1] Hu-Ping Wang et al."Based on the Dual Pathway of Interaction-Mediated NF-κB in Cell Apoptosis and Immune Inflammation to Study the Effect of Danzhi Xiaoyao Powder on the Learning and Cognitive Ability of AD Model Rats."Degenerative Neurological and Neurom
10. [IF=6.8] Zihan Cheng et al."Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide O-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease."JOURNAL OF MEDICINAL CHEMISTRY.2024;67(16):14292–14312
9. [IF=3.9] Si Xinxin et al."Discovery of a novel DYRK1A inhibitor with neuroprotective activity by virtual screening and in vitro biological evaluation."MOLECULAR DIVERSITY.2024 Jun;:1-14
8. [IF=2.4] Gao Shang et al."LncRNA ENST00000440246.1 Promotes Alzheimer’s Disease Progression by Targeting PP2A."BIOCHEMICAL GENETICS.2023 Oct;:1-17
7. [IF=14.224] Liubing Kong et al."Single-stranded DNA binding protein coupled aptasensor with carbon-gold nanoparticle amplification for marine toxins detection assisted by a miniaturized absorbance reader."JOURNAL OF HAZARDOUS MATERIALS.2023 May;450:131023
6. [IF=2.896] Chiyu Ma et al."A multi-channel handheld automatic spectrometer for wide range and on-site detection of okadaic acid based on specific aptamer binding."Anal Methods-Uk. 2021 Oct;13(38):4345-4353
5. [IF=4.418] Yiming Pan et al."Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid."Acs Chem Neurosci. 2021;12(8):1343–1350
4. [IF=3.701] Junjun Chen et al."Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway."J Funct Foods. 2016 Apr;22:463
3. 陶贵斌, 张天柱, 李朝政,等. 鹿茸多肽对冈田酸致大鼠HT22细胞损伤保护作用的实验研究[J]. 中国科技论文, 2017(18):93-97.
2. 林贺, 刘玥欣, 任吉祥,等. 鹿茸多肽对冈田酸诱导的小鼠海马神经元HT22细胞损伤模型中PI3K,AKT,Caspase-9表达的影响[J]. 人参研究, 2020, v.32;No.135(01):15-18.
1. 孙云鹏, 高莉, 罗静莺,等. 阿纳其根醇提物对冈田酸诱导PC12细胞损伤的保护作用[J]. 中成药, 2017, 39(009):1936-1939.
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