货号	规格	价格	上海	北京	武汉	南京
S30880-25g	98%	￥45.00 S30880-25g ￥45.00 现货	73 16 >10	10	4	2
S30880-100g	98%	￥90.00 S30880-100g ￥90.00 现货	4 10 4	4	1	5
S30880-500g	98%	￥270.00 S30880-500g ￥270.00 现货	18 >10	-	-	-

产品介绍

本品可降低Ⅱ型糖尿病患者空腹及餐后高血糖，糖化血红蛋白HbAlc可下降1%～2%，本品降血糖的机制可能是：①增加周围组织对胰岛素的敏感性,增加胰岛素介导的葡萄糖利用；②增加非胰岛素依赖的组织对葡萄糖的利用，如脑、血细胞、肾髓质、肠道、皮肤等；③抑制肝糖原异生作用，降低肝糖输出；④抑制肠壁细胞摄取葡萄糖；⑤抑制胆固醇的生物合成和贮存，降低血甘油三酯、总胆固醇水平。与胰岛素作用不同，本品无促进脂肪合成作用、对正常人无明显降血糖作用，对Ⅱ型糖尿病单独应用时一般不引起低血糖。储液配置

熔点：	223-226°C
沸点：	224.1°C at 760 mmHg
外观：	结晶固体
溶解性：	易溶于水，在甲醇中溶解，在乙醇中微溶，不溶于乙醚和氯仿。
储存条件：	RT
注意：	部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(22篇)

22. [IF=3.8] Hongyan Zhou et al."Flavonoids from Ougan (Citrus suavissima Hort. ex Tanaka) peel exert hypoglycemic potency through inhibiting insulin resistance in HepG2 cells and regulating gut microbiota in diabetic mice."Journal of Functional Foods.2024 Dec;123:106 21. [IF=4.7] Jingfang Xiong et al."Oxymatrine reduces hepatic lipid synthesis in rat models of nonalcoholic steatohepatitis by regulating Sirt1/AMPK and LXR/Plin2/SREBP-1c pathways."CHEMICO-BIOLOGICAL INTERACTIONS.2024 Dec;:111370 20. [IF=4.4] Tao Jiang et al."Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics."Frontiers in Pharmacology.2025 Feb;16: 19. [IF=6.7] Xu Wang et al."Discovery of the pharmacodynamic material basis of Danggui Buxue Decoction in the treatment of diabetic kidney disease based on lipidomics regulation."PHYTOMEDICINE.2025 Mar;:156643 18. [IF=4.8] Xinying Fu et al."Guhan Yangsheng Jing Mitigates Oxidative Stress and Ferroptosis to Improve Reproductive Damage in Diabetic Male Rats."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;:119746

17. [IF=5.6] Qiangsheng Li et al."Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF-β1/Smads signaling pathway."INTERNATIONAL IMMUNOPHARMACOLOGY".2024 May;133:112131 16. [IF=5] Qian Yu et al."Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 May;971:176529 15. [IF=5.2] Ziang Ma et al."Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats."Frontiers in Endocrinology.10.3389/fendo.2023.1159707 14. [IF=6.168] Du Peiyu et al."SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro."ARCHIVES OF TOXICOLOGY.2023 Feb;:1-16 13. [IF=5.396] Kaixi Wang et al."Transcriptome analysis provides insight into the anti-diabetic mechanism of theaflavins in high-fat diet and streptozotocin-induced mice."Food Funct. 2022 Jan;: 12. [IF=7.086] Xing-Bo Song et al."Assessment of metformin, nicotine, caffeine, and methamphetamine use during Chinese public holidays."Chemosphere. 2020 Nov;258:127354 11. Yao, Ye, et al. "Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids." Biomedicine & Pharmacotherapy 131 (2020): 110669.https://doi.org/10.1016/j.biopha.2020.110669 10. Song, Xing-Bo, et al. "Assessment of metformin, nicotine, caffeine, and methamphetamine use during Chinese public holidays." Chemosphere 258 (2020): 127354.https://doi.org/10.1016/j.chemosphere.2020.127354 9. 曹宇,许璐,李凯峰,朱翰朝,李瑶,李捷,段维勋,王四旺,汤海峰.桑叶提取物对糖尿病小鼠心肌保护作用的研究[J].心脏杂志,2021,33(01):17-23. 8. 刘佳佳,李丹丹,赵翊,吴玉泓,王晶.黄芪多糖联合二甲双胍对衰老糖尿病小鼠肝脏mRNA表达谱的影响及功能分析[J].时珍国医国药,2020,31(05):1043-1046. 7. 李丹丹, 刘佳佳, 吴玉泓,等. 黄芪多糖联合二甲双胍对衰老2型糖尿病模型小鼠肝脏糖脂代谢的影响[J]. 中国中医药信息杂志, 2019, 26(02):47-51. 6. 杨艳华,林素静,刘西京,杜斌. 长裂苦苣菜萃取物对胰岛素抵抗HepG2细胞糖代谢的影响[J]. 深圳职业技术学院学报(1期):45-49. 5. 杨欢杰,张海波,徐蕊,高惠静,袁圆,赵军.离子交换色谱法测定健康人血浆和尿中的盐酸二甲双胍浓度[J].中国临床药理学杂志,2017,33(09):821-824. 4. 顾员印, 丁淑梅, 孙翠翠,等. 白凤菜对机体糖耐量影响的研究[J]. 中国畜牧兽医, 2017, 44(005):1547-1551. 3. 王晓彤,林海雄,郭爱琳,李志城,丘树林,李明珠,张韧.玉竹及其多糖对2型糖尿病大鼠血糖血脂及坐骨神经NGF mRNA表达的影响[J].中华中医药学刊,2017,35(05):1177-1180+1351. 2. 刘长河付茜李斌潘一龙刘贞李晓东.二甲双胍调节糖尿病大鼠心房小电导钙激活钾通道亚型蛋白表达的信号通路[J].中华老年心脑血管病杂志 2020 22(01):70-74. 1. 刘超高慧婕杨强强等. 二甲双胍对脂多糖致炎性反应小鼠的抗炎作用[J]. 基础医学与临床 2019(9).

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盐酸二甲双胍

1,1-Dimethylbiguanide hydrochloride