货号	规格	价格	上海	北京	珠海	重庆	武汉
S40691-1mg买3赠1	≥95%	￥800.00 S40691-1mg ￥800.00 现货（买3赠1）	1 5 1	1	-	-	4
S40691-5mg买3赠1	≥95%	￥2500.00 S40691-5mg ￥2500.00 2-3天（买3赠1）	0 0 货期：2-3天	-	-	-	-
S40691-10mg买3赠1	≥95%	￥4000.00 S40691-10mg ￥4000.00 2-3天（买3赠1）	0 0 货期：2-3天	-	-	-	-

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产品描述：

Amino Acid Sequence Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

β-淀粉样蛋白聚集指南 (此方法仅供参考，可根据具体实验进行修改)。

1. 将β-淀粉样多肽 1-42溶解在冷的六氟-2-丙醇 (HFIP) 中) .在室温下孵育至少1小时以建立单体化和结构随机化。

2. 通过蒸发去除HFIP，并将所得肽以薄膜形式储存在 -20或 -80℃。

3. 将得到的膜以5mM浓度溶解在无水DMSO中，然后涡旋稀释成合适的浓度和缓冲液 (无血清和酚红的培养基)。

4. 接下来，将溶液在 4-8°C 下 48 小时。然后将样品在 4-8°C 下以 14000g 离心 10 分钟；可溶性低聚物在上清液中。将上清液稀释 10 -200 倍用于实验。具体稀释浓度根据实验而定。

注意：

聚集形式在溶液中不稳定，建议立即使用。

体内研究：

注意：
请勿仅参考一篇文章来确定实验条件。建议在正式实验前，通过预实验确定最佳实验条件 (动物品系、年龄、剂量、频率及周期、检测时间及指标等)。

β-Amyloid (1-42), human TFA 可用于动物建模，构建阿尔兹海默症模型。

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.222 ml	1.108 ml	2.215 ml
5 mM	0.044 ml	0.222 ml	0.443 ml
10 mM	0.022 ml	0.111 ml	0.222 ml
50 mM	0.004 ml	0.022 ml	0.044 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(14篇)

14. [IF=16] Huangjuan Li, et al. "A Preventable Alzheimer’s Disease Microneedle Patch with Synaptic Protection and NLRP3 Inflammasome Suppression in Microglia during Smoking Cessation"ACS Nano, 2026-02-16 13. [IF=15] Yinjia Li, et al. "A novel nasal mucosal peptide-modified co-delivery system for ginsenoside Rg1, Rb1, and notoginseng saponin R1 in the amelioration of AD"JOURNAL OF NANOBIOTECHNOLOGY, 2026 May 12 12. [IF=16] Ying Wang et al."Modulating Amyloid Pathology–Neural Hyperexcitability Crosstalk for Alzheimer’s Disease Therapy."ACS Nano.2025;19(43):37617–37632 11. [IF=2.3] Bin Wang et al."Amyloid β (Aβ) inhibits retinal angiogenesis in Alzheimer's disease via LncRNA-XIST/miRNA-126-5p/VEGF axis."IMMUNOBIOLOGY.2025 Jul;:153097 10. [IF=3.5] Xu Zhiguo et al."An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer’s disease in rats."METABOLIC BRAIN DISEASE.2025 Aug;40(6):1-16

9. [IF=2.3] Xingyuan Wang et al."Screening for Anti-Aβ Aggregation Activity of Marine Fungal Natural Products Based on a Gold Nanoparticle Method."CHEMISTRY & BIODIVERSITY.2024 Dec;:e202401809 8. [IF=4.9] Jun Li et al."Advanced Nanopharmaceutical Intervention for the Reduction of Inflammatory Responses and the Enhancement of Behavioral Outcomes in APP/PS1 Transgenic Mouse Models."Pharmaceutics.2025 Feb;17(2):177 7. [IF=4.3] Na Li et al."Photobiomodulation ameliorates neuronal damage in an amyloid-beta induced rat model."IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS.2025 Apr;PP(99):1-8 6. [IF=5.4] Jiayi Zhi et al."Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;319:117291 5. [IF=2.8] Cao Xiaona et al."Ultrasensitive FET biosensor chip based on self-assembled organic nanoporous membrane for femtomolar detection of Amyloid-β."BIOMEDICAL MICRODEVICES.2023 Sep;25(3):1-9 4. [IF=6.911] Miao Chen et al."A label-free dually-amplified aptamer sensor for the specific detection of amyloid-beta peptide oligomers in cerebrospinal fluids."ANALYTICA CHIMICA ACTA.2023 May;:341298 3. [IF=3.038] Pan Junlu et al."Brain Microvascular Endothelial Cell Derived Exosomes Potently Ameliorate Cognitive Dysfunction by Enhancing the Clearance of Aβ Through Up-Regulation of P-gp in Mouse Model of AD."Neurochem Res. 2020 Sep;45(9):2161-2172 2. [IF=7.328] Qinghao Huo et al."Biomimetic silibinin-loaded macrophage-derived exosomes induce dual inhibition of Aβ aggregation and astrocyte activation to alleviate cognitive impairment in a model of Alzheimer's disease."Mat Sci Eng C-Mater. 2021 Oct;129:112365 1. 高爱社,杨洒,张振强,宋军营,张鹏飞,史占江.丹蒌片对Aβ_(1-40)致脑微血管内皮细胞损伤保护作用的机制研究[J].中药新药与临床药理,2021,32(02):234-239.

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

β-淀粉样多肽 1-42

Amyloid β Protein Fragment 1-42

参考文献(14篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)