GW9662 ≥98%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S44800-10mg |
≥98% | ￥80.00 |
>10 | - | 2 | - | - |
|
S44800-50mg |
≥98% | ￥300.00 |
>10 | 2 | - | - | - |
|
S44800-250mg |
≥98% | ￥900.00 |
>10 | - | - | - | - |
|
产品介绍
GW9662是一种选择性PPAR拮抗剂，作用于PPARγ，IC50为3.3 nM，作用于PPARγ比作用于PPARα和PPARδ选择性强100到1000倍。
| SMILES： | O=C(NC1=CC=CC=C1)C2=CC([N+]([O-])=O)=CC=C2Cl |
|---|---|
| 熔点： | 171-175℃ |
| 溶解性： | Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1:2 DMF : PBS (PH=7.2) (~0.5 mg/ml). Insolub |
| 储存条件： | 2-8℃ |
| 用途： | A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist. |
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(7篇)
7. [IF=4.2] Dao-ming Zhang et al."Ginsenoside Rg5 Improves Radiation-Induced Heart Injury via PPARG/PDK1/AKT1 Pathway."JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2025 Oct;29(20):e70852
6. [IF=4.8] Junfeng Li et al."Ameliorative potential of ellagic acid via PPARγ against hyperlipidemia: Insights from mice and zebrafish."Food Bioscience.2024 Nov;:105582
5. [IF=3.8] Peiyu Xue et al."PPARγ-mediated amelioration of lipid metabolism abnormality by kaempferol."ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.2024 Nov;761:110154
4. [IF=3.5] Guangjie Zhang et al."Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice."Food Science & Nutrition.2024 Aug;:
3. [IF=3.8] Zilong Zhang et al."Bivalent affinity binding-inspired PPARγ immobilization with selective conformation and improved ligand-binding activity."JOURNAL OF CHROMATOGRAPHY A.2024 Aug;1730:465141
2. [IF=3.4] Zhang Ningzhi et al."PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats."Journal of Cardiovascular Translational Research".2024 Feb;:1-13
1. [IF=5.279] Jing Zhou et al."Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway."J Agr Food Chem. 2021;69(32):9299–9312
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