货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S53158-1ml	10mM in DMSO	￥720.00 S53158-1ml ￥720.00 现货	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S53158-1ml

10mM in DMSO

￥720.00

产品描述：

LPA 受体拮抗剂;LPA Receptor Antagonists;;InformationAM 095 AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.TargetsLPA1 receptorIn vitroAM095 is a potent LPA1 receptor antagonist because it inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM).In vivoAM095 has high oral bioavailability and a moderate half-life and is well tolerated at the doses tested in rats and dogs after oral and intravenous dosing. It dose-dependently reduceS LPA-stimulated histamine release, attenuated bleomycin-induced increases in collagen, protein, and inflammatory cell infiltration in bronchalveolar lavage fluid, and decreases kidney fibrosis in a mouse unilateral ureteral obstruction model. Despite its antifibrotic activity, AM095 has no effect on normal wound healing after incisional and excisional wounding in rats.

靶点：

IC50: 0.98 μM (human LPA1), 0.73 μM (mouse LPA1)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.191 ml	10.953 ml	21.906 ml
5 mM	0.438 ml	2.191 ml	4.381 ml
10 mM	0.219 ml	1.095 ml	2.191 ml
50 mM	0.044 ml	0.219 ml	0.438 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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