| 产品描述： | 脱氢酶抑制剂;Dehydrogenase Inhibitors;;InformationAG-636 AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.TargetsDHODHIn vitroAG-636 reveals a strong enrichment in sensitivity to a novel dihydroorotate dehydrogenase (DHODH) in cancer cell lines of hematologic versus solid tumor origin.In vivoAG-636 results in robust tumor growth inhibition in xenograft lymphoma tumor models, with comparably poor activity in solid tumor models.Cell Research(from reference)Cell lines：Z138 cells, OCILY19 cells, JEKO1 cells, HCT116 cells, A549 cells Concentrations：10 μM Incubation Time：96 h |
| 靶点： |
IC50: 17 nM (Dihydroorotate dehydrogenase (DHODH)) |
| 体内研究： |
AG-636 (10-100 mg/kg；灌胃；每天两次；持续 14 天) 处理可在 OCILY19 DLBCL 肿瘤异种移植模型中产生强烈的肿瘤生长抑制。 |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.912 ml |
14.561 ml |
29.122 ml |
| 5 mM |
0.582 ml |
2.912 ml |
5.824 ml |
| 10 mM |
0.291 ml |
1.456 ml |
2.912 ml |
| 50 mM |
0.058 ml |
0.291 ml |
0.582 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京