| 产品描述： | PDE 抑制剂;PDE Inhibitors;;InformationBI-409306 BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.Targetshuman PDE9A (Cell-free assay); rat PDE9A (Cell-free assay) 65 nM; 168 nM |
| 参考文献： |
1. Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.212 ml |
16.06 ml |
32.119 ml |
| 5 mM |
0.642 ml |
3.212 ml |
6.424 ml |
| 10 mM |
0.321 ml |
1.606 ml |
3.212 ml |
| 50 mM |
0.064 ml |
0.321 ml |
0.642 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京