货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S54124-1ml促销	10mM in DMSO	￥720.00 ￥648.00 S54124-1ml ￥648.00 现货	8 8	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S54124-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

C-Raf/Raf-1 选择性抑制剂;C-Raf/Raf-1 Selective Inhibitors;;InformationCCT196969 is a novel orally available, pan-RAFinhibitor with anti-SRCactivity. It also inhibits SRC, LCK, and the p38 MAPKs.TargetsCRAF (Cell-free assay); LCK (Cell-free assay); Src (Cell-free assay); V600E-BRAF (Cell-free assay); BRAF (Cell-free assay) ;0.01 μM; 0.02 μM; 0.03 μM; 0.04 μM; 0.1 μMIn vitroCCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF, but not cancer cells that are wild-type for BRAF and NRAS. CCT196969 induces caspase 3 and PARP cleavage, thus induces apoptosis. CCT196969 does not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma.In vivoCCT196969 is extremely well tolerated at the doses assessed and does not produce any significant adverse effects in vivo. Oral dosing at 10 mg/kg/day of CCT196969 results in plasma concentrations ∼1 μM at 24 hr. It is orally bioavailable at ∼55%.Cell Research(from reference)Cell lines：cell line derived from a vemurafenib-resistant melanoma Concentrations：1 μM Incubation Time：4 h

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.947 ml	9.737 ml	19.473 ml
5 mM	0.389 ml	1.947 ml	3.895 ml
10 mM	0.195 ml	0.974 ml	1.947 ml
50 mM	0.039 ml	0.195 ml	0.389 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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