丝氨酸/苏氨酸激酶抑制剂;Serine/threonin kinase Inhibitors;;InformationHPK1-IN-2 HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase) , Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity.TargetsHPK1 (Cell-free assay); Flt3 (Cell-free assay); Lck (Cell-free assay) 0.05 μM; 0.05 μM; 0.5 μM