| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S55502-1mg促销 |
98% | ￥756.00 ￥680.00 |
货期：3-5天 | - | - | - | - |
|
S55502-5mg促销 |
98% | ￥2640.00 ￥2370.00 |
7 | - | - | - | - |
|
S55502-10mg促销 |
98% | ￥4350.00 ￥3910.00 |
5 | - | - | - | - |
|
S55502-25mg促销 |
98% | ￥7630.00 ￥6860.00 |
3 | - | - | - | - |
|
S55502-50mg促销 |
98% | ￥12100.00 ￥10900.00 |
2 | - | - | - | - |
|
S55502-100mg促销 |
98% | ￥15200.00 ￥13700.00 |
3 | - | - | - | - |
|
| 靶点： | Ki: 97.4 nM (human SGLT1), 43.5 nM (rat SGLT1) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究： | In the oral glucose tolerance test with streptozotocin-induced diabetic rats, KGA-2727 attenuates the elevation of plasma glucose after glucose loading, indicating that KGA-2727 improves postprandial hyperglycemia. In Zucker diabetic fatty (ZDF) rats, chronic treatments with KGA-2727 reduces the levels of plasma glucose and glycated hemoglobin. Furthermore, KGA-2727 preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats. |
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| 参考文献： | 1. Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96. | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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