C-Raf/Raf-1 选择性抑制剂;C-Raf/Raf-1 Selective Inhibitors;;InformationMCP110 is an inhibitor ofRas/Raf-1interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.TargetsRaf-1 ; Ras-Raf interaction
参考文献:
1. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.