马来酰亚胺(2,5-吡咯二酮)是一种新型纳米颗粒表面官能团,易于与细胞穿透肽偶联。通过点击化学可实现偶联,同时保留其生物功能.;Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.The maleimide-functionalized silica beads were used to immobilize the bovine serum albumin (BSA)-boronic acid (BA) conjugates.
体内研究:
Maleimide 修饰的脂质体 (M-GGLG-liposomes, 2 mg/kg, sc, twice in an interval of 2 weeks) 小鼠模型中表现出抗肿瘤作用,且具有更好且长期的疗效。