| 产品描述: | 真菌抑制剂;Fungal Inhibitors;;InformationNeticonazole Hydrochloride Neticonazole is an imidazole antifungal for the treatment of fungal skin infections. |
| 靶点: |
Fungal |
| 体内研究: |
Neticonazole (1-100 ng/kg;口服管饲法;每天;持续 15 天;雄性 C57BL/6 小鼠) 处理显著改善肠道菌群失调 (IDB) 小鼠结直肠癌 (CRC) 异种移植肿瘤的存活率,这可能是通过增加 CRC 异种移植肿瘤细胞的凋亡来实现的。 |
| 参考文献: |
1. Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3. 2. Datta A, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. 3. Gu L, et al. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020 Apr;38(2):221-228. |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.951 ml |
14.754 ml |
29.507 ml |
| 5 mM |
0.59 ml |
2.951 ml |
5.901 ml |
| 10 mM |
0.295 ml |
1.475 ml |
2.951 ml |
| 50 mM |
0.059 ml |
0.295 ml |
0.59 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |