脱氢酶抑制剂;Dehydrogenase Inhibitors;;InformationNCT-501 NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.TargetsALDH1A1 40 nMIn vitroIn Caco-2 cell line, NCT-501 exhibits excellent permeability.In vivoIn CD1 Mice, NCT-501 is well absorbed and distributed but rapidly metabolized and/or excreted.