货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S56223-1ml促销	10mM in DMSO	￥720.00 ￥648.00 S56223-1ml ￥648.00 现货	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S56223-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

LPA 受体拮抗剂;LPA Receptor Antagonists;;InformationONO-7300243 ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.TargetsLPA1 (Cell-free assay) 0.16 μMIn vitroAlthough ONO-7300243 showed only modest in vitro activity (IC50 = 0.16 μM), it showed much stronger effects in vivo (88% inhibition at 10 mg/kg i.d., 62% inhibition at 3 mg/kg i.d.). ONO-7300243 showed good membrane permeability and good metabolic stability against rat liver microsomes.In vivoONO-7300243 inhibited the LPA-induced IUP(intraurethral pressure) increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p<0.05 vs vehicle). ONO-7300243 (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP). In a a rat pharmacokinetic study, ONO-7300243 showed a rapid clearance (CLtot = 15.9 mL/min/kg at 3 mg/kg i.v.) and a short half-life (0.3 h).Cell Research(from reference)Cell lines：Chinese hamster ovary (CHO) cells

靶点：

IC50: 0.19-0.13 μM (LPA1)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.167 ml	10.833 ml	21.666 ml
5 mM	0.433 ml	2.167 ml	4.333 ml
10 mM	0.217 ml	1.083 ml	2.167 ml
50 mM	0.043 ml	0.217 ml	0.433 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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