β-肾上腺素能受体选择性抑制剂| 激动剂 | 拮抗剂;β-adrenergic receptor Selective Inhibitors | Agonists | Antagonists;;InformationPropafenone (SA-79) is an orally activesodium channelblocking agent and abeta-adrenoceptor (β-adrenergic receptor)antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.Targetssodium channel ; β-adrenergic receptor
体内研究:
Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%. Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group).