| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S56515-1ml促销 |
10mM in DMSO | ￥309.00 ￥240.00 |
8 | - | - | - | - |
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| 产品描述： | Pinacidil is a K+ channel opener. Pinacidil is demonstrated to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. This action is suppressed by the ATP-dependent K+ (KATP) channel blockers Glibenclamide and Tetrapentylammonium salts, suggesting that relaxations induced by Pinacidil are mediated by opening of KATP channels.;Pinacidil is a K+ channel opener. Pinacidil is demonstrated to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. This action is suppressed by the ATP-dependent K+ (KATP) channel blockers Glibenclamide and Tetrapentylammonium salts, suggesting that relaxations induced by Pinacidil are mediated by opening of KATP channels.A K+ channel activator; antihypertensive | ||||||||||||||||||||
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| 体内研究： | Pinacidil (3-30 μg，静脉注射，单次给药) monohydrate 在非糖尿病小鼠 (ED50 = 16.1)和糖尿病小鼠 (ED50 = 22.3) 中呈剂量依赖性地增加甩尾反应潜伏期。 Pinacidil (10-100 μg，i.t.，单次给药) monohydrate 在糖尿病小鼠中产生剂量依赖性显著的抗伤害作用，而 100 μg 剂量在非糖尿病小鼠中没有产生显著的抗伤害作用 (ED50 = 18.5)，而糖尿病小鼠的 ED50 为 95.6。 Pinacidil (30 μg，静脉注射，单次给药) monohydrate 不受 β-Funaltrexamine (20 和 40 mg/kg，皮下注射) 预处理对糖尿病小鼠的抗伤害作用的影响。 Pinacidil (30 μg，i.t.，单次给药) monohydrate 会剂量依赖性地降低 β-Funaltrexamine (20 和 40 mg/kg，s.c.) 的抗伤害作用，且该作用可被 7-Benzylidenenaltrexon (0.3 mg/kg)、Naltriben (0.3 mg/kg) 或 nor-Binaltorphimine (20 mg/kg，s.c.) 预处理所拮抗。 |
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| 参考文献： | 1. Hamilton TC, et al., Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20(1):1-9. 2. Jung-Ae Kim, et al., Activation of Na+, K+, Cl−-Cotransport Mediates Intracellular Ca2+ Increase and Apoptosis Induced by Pinacidil in HepG2 Human Hepatoblastoma Cells, Biochemical and Biophysical Research Communications, Volume 281, Issue 2, 2001, Pages 511-519, ISSN 0006-291X,3. Weston, A.H., et al., In Vitro Studies on the Mode of Action of Pinacidil. Drugs 36 (Suppl 7), 10–28 (1988). 4. Ko Zushida, et al ., Effect of diabetes on pinacidil-induced antinociception in mice, European Journal of Pharmacology, Volume 453, Issues 2–3, 2002, Pages 209-215, ISSN 0014-2999. |
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| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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