| 产品描述: | 高选择性,不可逆的MAO-B抑制剂;Highly selective, irreversible MAO-B inhibitor;Rasagiline是一种选择性的、不可逆的MAO-B炔丙胺抑制剂,对MAO-B和MAO-A的IC50分别为4.43 nM和412 nM。甲磺酸雷沙吉兰可被用于MAO B型介导的细胞信号转导研究。;Rasagiline mesylate has been used:• to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation• as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model• as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior. |