PDE5 选择性抑制剂;PDE5 Selective Inhibitors;;InformationSildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor ofPhosphodiesterase 5.TargetsPDE5In vivoChronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges.
参考文献:
1. Haider M, et al. The Potential Role of Sildenafil in Cancer Management through EPR Augmentation. J Pers Med. 2021 Jun 21;11(6):585.