| 产品描述： | 一种正在开发中的药物，旨在作为沉默调节蛋白SIRT1亚型的小分子激活剂。;a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1.;SRT 1460是一种开发中的药物，旨在作为Sirtuin亚型SIRT1的小分子激活剂。SRT 1460显示出SIRT1对SIRT2和SIRT3的正选择性。在动物研究中，SRT 1460被证明与白藜芦醇（一种已知的SIRT1激活剂）具有相似的活性。但是，SRT 1460的效价比白藜芦醇更接近SRT 1720。在动物研究中观察到SRT 1460可改善胰岛素敏感性，降低血浆葡萄糖水平并增加线粒体的代谢功能。;SRT 1460 is a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1. SRT 1460 shows positive selectivity of SIRT1 versus SIRT2 and SIRT3. In animal studies, SRT 1460 was shown to have similar activity to resveratrol, a known SIRT1 activator. SRT 1460, however, is closer in potency to SRT 1720 than it is to resveratrol. SRT 1460 was observed in animal studies improving insulin sensitivity, lowering plasma glucose levels, and increasing metabolic function in mitochondria. |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
