货号	规格	价格	上海	北京	珠海	重庆	武汉
S80013-5mg买3赠1	98.10%	￥182.00 S80013-5mg ￥182.00 现货（买3赠1）	106 >10	-	-	-	-
S80013-10mg买3赠1	98.10%	￥204.00 S80013-10mg ￥204.00 现货（买3赠1）	61 >10	-	-	-	-
S80013-25mg买3赠1	98.10%	￥476.00 S80013-25mg ￥476.00 现货（买3赠1）	28 >10	-	-	-	-
S80013-50mg买3赠1	98.10%	￥612.00 S80013-50mg ￥612.00 现货（买3赠1）	14 0 >10	-	-	-	-
S80013-100mg买3赠1	98.10%	￥1070.00 S80013-100mg ￥1070.00 现货（买3赠1）	9 9	-	-	-	-
S80013-200mg	≥98%	￥1630.00 S80013-200mg ￥1630.00 现货	2 2	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2

靶点：

mTOR:0.8 nM (IC50);mTORC1;mTORC2;Autophagy;Apoptosis;mTOR;Autophagy

体内研究：

In mice bearing U87-MG (PTEN null) glioblastoma xenografts, oral treatment with AZD-8055 (AZD8055) results in a dose-dependent tumor growth inhibition of 33%, 48%, and 77% with 2.5, 5, and 10 mg/kg/d twice daily, respectively. A similar dose dependency is observed in nude mice bearing A549 xenografts: tumor growth inhibition is 44%, 55%, and 93% after 2.5, 5, and 10 mg/kg/d twice daily, respectively. AZD8055 also results in significant inhibition of tumor growth and/or regression in breast, lung, colon, prostate, and uterine xenograft models when administered either twice daily at 10 mg/kg or daily at a dose of 20 mg/kg. AZD8055 markedly decreases the phosphorylation levels of mTOR and its substrates and the activation of microglia in vivo, and promotes the microglial polarization from M1 phenotype to M2 phenotype. In addition, administration of AZD8055 following subarachnoid hemorrhage (SAH) significantly ameliorates EBI, including neuronal apoptosis, neuronal necrosis, brain edema and blood-brain barrier permeability

参考文献：

1. Chresta CM, et al. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res, 2010, 70(1), 288-298.2. You W, et al. Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats. J Neurol Sci. 2016 Aug 15;367:224-31. 3. Kawata T, et al. Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. Cancer Sci. 2017 Oct 27.

溶解性：

DMSO : 33.33 mg/mL (71.59 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.148 ml	10.74 ml	21.48 ml
5 mM	0.43 ml	2.148 ml	4.296 ml
10 mM	0.215 ml	1.074 ml	2.148 ml
50 mM	0.043 ml	0.215 ml	0.43 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(2篇)

2. [IF=3.4] Chongyang Wu et al."Interactive Effects of Exogenous Hormones, Sucrose, and Environmental Factors on the Growth of Phyllostachys edulis Shoots."Agronomy-Basel.2025 Sep;15(9):2095 1. [IF=3.4] Chongyang Wu et al."Interactive Effects of Exogenous Hormones, Sucrose, and Environmental Factors on the Growth of Phyllostachys edulis Shoots."Agronomy-Basel.2025 Sep;15(9):2095

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

AZD8055

(5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

参考文献(2篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)