| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80016-5mg买3赠1 |
98.20% | ￥272.00 |
8 | - | - | - | - |
|
S80016-10mg买3赠1 |
98.20% | ￥384.00 |
3 | - | - | - | - |
|
S80016-25mg买3赠1 |
98.20% | ￥800.00 |
4 | - | - | - | - |
|
S80016-50mg买3赠1 |
98.20% | ￥1520.00 |
5 | - | - | - | - |
|
S80016-100mg买3赠1 |
98.20% | ￥2240.00 |
3 | - | - | - | - |
|
S80016-200mg买3赠1 |
≥98% | ￥3600.00 |
货期：2-3天 | - | - | - | - |
|
S80016-250mg买3赠1 |
≥98% | ￥4000.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | UCHL5/Usp14;Apoptosis;DUB | ||||||||||||||||||||
| 体内研究： | b-AP15 (2.5 mg/kg) inhibits tumor growth in syngenic mice models with less frequent administration schedules. We administered b-AP15 to C57BL/6J mice with Lewis lung carcinomas (LLCs) using a 2-d-on, 2-d-off schedule and to BALB/c mice with orthotopic breast carcinoma (4T1) using a 1-d-on, 3-d-off schedule. b-AP15 significantly inhibited tumor growth in both models, with T/C=0.16 (P≤0.01) for the C57BL/6J mice and T/C=0.25 (P≤0.001) for the BALB/c mice. A reduction in the number of pulmonary metastases also is observed in the group of mice with 4T1 breast carcinomas treated with b-AP15 | ||||||||||||||||||||
| 参考文献： | 1. D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40. 2. Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45. 3. Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16. | ||||||||||||||||||||
| 溶解性： | DMSO : 20 mg/mL (47.69 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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