源叶(MedMol)
S80017
一键复制产品信息
1009820-21-6
C19H12ClN3O2
349.77
5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid
CX-4945 (Silmitasertib) 99.70%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80017-1mg买3赠1 |
99.70% | ￥200.00 |
4 | 2 | 2 | - | - |
|
S80017-2mg买3赠1 |
99.70% | ￥344.00 |
3 | - | - | - | - |
|
S80017-5mg买3赠1 |
99.70% | ￥536.00 |
6 | - | - | - | - |
|
S80017-10mg买3赠1 |
99.70% | ￥880.00 |
6 | - | - | - | - |
|
S80017-25mg买3赠1 |
99.70% | ￥1520.00 |
8 | - | - | - | - |
|
S80017-50mg买3赠1 |
99.70% | ￥2560.00 |
7 | - | - | - | - |
|
S80017-100mg买3赠1 |
99.70% | ￥4800.00 |
4 | - | - | - | - |
|
| 产品描述： | Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | CK2α:1 nM (IC50);CK2α':1 nM (IC50);CaseinKinase;Autophagy | ||||||||||||||||||||
| 体内研究： | Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models | ||||||||||||||||||||
| 参考文献： | 1. Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. 2. Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. 3. Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 35 mg/mL (100.07 mM) 0.1 M NaOH : 33.33 mg/mL (95.29 mM; ultrasonic and adjust pH to 9 with NaOH) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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