Tenovin 6 99.60%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80019-1mg买3赠1 |
99.60% | ￥435.00 |
9 | - | - | - | - |
|
S80019-5mg买3赠1 |
99.60% | ￥760.00 |
5 | - | - | - | - |
|
S80019-10mg促销 |
99.60% | ￥1460.00 ￥1160.00 |
6 | - | - | - | - |
|
S80019-25mg促销 |
99.60% | ￥2220.00 ￥1770.00 |
5 | - | - | - | - |
|
S80019-50mg促销 |
≥98% | ￥4420.00 ￥3530.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) | ||||||||||||||||||||
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| 靶点： | SIRT2:10 μM (IC50);SIRT1:21 μM (IC50);SIRT3:67 μM (IC50);HDAC8;MDM-2/p53;Dehydrogenase;Sirtuin;Autophagy | ||||||||||||||||||||
| 体内研究： | Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice | ||||||||||||||||||||
| 参考文献： | 1. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. 2. Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. 3. Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622. 4. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608. 5. Yuan H, et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 31 mg/mL (68.19 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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