货号	规格	价格	上海	北京	珠海	重庆	武汉
S80032-1mg买3赠1	99.14%	￥100.00 S80032-1mg ￥100.00 现货（买3赠1）	6 6	-	-	-	-
S80032-5mg买3赠1	99.14%	￥312.00 S80032-5mg ￥312.00 现货（买3赠1）	12 >10	-	-	-	-
S80032-10mg买3赠1	99.14%	￥450.00 S80032-10mg ￥450.00 现货（买3赠1）	8 8	-	-	-	-
S80032-25mg买3赠1	99.14%	￥550.00 S80032-25mg ￥550.00 现货（买3赠1）	3 3	-	-	-	-
S80032-50mg买3赠1	99.14%	￥880.00 S80032-50mg ￥880.00 现货（买3赠1）	5 5	-	-	-	-
S80032-100mg买3赠1	99.14%	￥1400.00 S80032-100mg ￥1400.00 现货（买3赠1）	5 0 5	-	-	-	-

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产品描述：

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity

靶点：

Aurora A:1.2 nM (IC50);Aurora B:396.5 nM (IC50);Apoptosis;AuroraKinase;Autophagy

体内研究：

Alisertib (MLN 8237) (30 mg/kg, p.o.) significantly reduces tumor burden and increases overall survival in xenograft-murine model of human-MM. Alisertib (3-30 mg/kg; p.o.; once daily for 3 weeks) causes tumor growth inhibition in solid tumor xenograft models.

参考文献：

1. Güllü G, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood June 24, 2010 vol. 115 no. 25 5202-5213. 2. Sloane DA, et al. Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 ACS Chem. Biol., 2010, 5 (6), pp 563-576. 3. Bavetsias V, et al. Aurora Kinase Inhibitors: Current Status and Outlook. Front Oncol. 2015 Dec 21;5:278. 4. Manfredi MG, et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.Clin Cancer Res. 2011 Dec 15;17(24):7614-7624.

溶解性：

DMSO : 25 mg/mL (48.18 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.927 ml	9.635 ml	19.27 ml
5 mM	0.385 ml	1.927 ml	3.854 ml
10 mM	0.193 ml	0.964 ml	1.927 ml
50 mM	0.039 ml	0.193 ml	0.385 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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