Clinafloxacin

99.10%

Clinafloxacin

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品牌：源叶(MedMol)

产品编号：S80061 一键复制产品信息

CAS号：105956-97-6

分子式：C₁₇H₁₇ClFN₃O₃

分子量：365.787

别名：克林沙星;7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸;1-环丙基-6-氟-7-(3-氨基吡咯烷-1- 基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸;可林沙星;7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecar

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80061-10mg买3赠1	99.10%	￥280.00 S80061-10mg ￥280.00 现货（买3赠1）	6 6	-	-	-	-
S80061-50mg买3赠1	99.10%	￥730.00 S80061-50mg ￥730.00 现货（买3赠1）	5 5	-	-	-	-
S80061-250mg买3赠1	99.10%	￥2400.00 S80061-250mg ￥2400.00 现货（买3赠1）	3 0 3	-	-	-	-
S80061-1g	≥98%	￥8000.00 S80061-1g ￥8000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro. Clinafloxacin is against DNA gyrase and topoisomerase IV of S. aureus with IC50 values of 0.92 µg/ml and 1.62 µg/ml, respectively

靶点：

Quinolone;Antibacterial;Antibiotic

体内研究：

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.

参考文献：

1. M Takei, et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. 2. Randa H Abdelkreem, et al. DNA Gyrase and Topoisomerase IV Mutations and their effect on Quinolones Resistant Proteus mirabilis among UTIs Patients. Pak J Med Sci. Sep-Oct 2020;36(6):1234-1240. 3. A Domenech, et al. Experimental study of clinafloxacin alone and in combination in the treatment of ciprofloxacin-susceptible and -resistant pneumococcal meningitis.Microb Drug Resist. 2003;9 Suppl 1:S53-9.

溶解性：

DMSO : 2 mg/mL (5.47 mM; ultrasonic and warming and heat to 80°C)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.734 ml	13.669 ml	27.338 ml
5 mM	0.547 ml	2.734 ml	5.468 ml
10 mM	0.273 ml	1.367 ml	2.734 ml
50 mM	0.055 ml	0.273 ml	0.547 ml