Sertindole

95.50%

Sertindole

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品牌：源叶(MedMol)

产品编号：S80070 一键复制产品信息

CAS号：106516-24-9

分子式：C₂₄H₂₆ClFN₄O

分子量：440.94

别名：舍吲哚;1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑啉酮;Sertindole; 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one; 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S80070-10mg	95.50%	￥330.00 S80070-10mg ￥330.00 现货	8 8	-	-	-	-
S80070-50mg	95.50%	￥1220.00 S80070-50mg ￥1220.00 现货	4 0 4	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.

靶点：

5-HT2A Receptor;5-HT2C Receptor;DopamineReceptor;5-HTReceptor;AdrenergicReceptor;Autophagy

体内研究：

Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo

参考文献：

1. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. 2. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753. 3. Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85.

溶解性：

DMSO : 25 mg/mL (56.70 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.268 ml	11.339 ml	22.679 ml
5 mM	0.454 ml	2.268 ml	4.536 ml
10 mM	0.227 ml	1.134 ml	2.268 ml
50 mM	0.045 ml	0.227 ml	0.454 ml