| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80084-5mg促销 |
≥98% | ￥395.00 ￥355.00 |
10 | - | - | - | - |
|
S80084-10mg促销 |
≥98% | ￥526.00 ￥474.00 |
10 | - | - | - | - |
|
S80084-25mg促销 |
≥98% | ￥702.00 ￥632.00 |
9 | - | - | - | - |
|
S80084-50mg促销 |
≥98% | ￥1250.00 ￥1120.00 |
8 | - | - | - | - |
|
S80084-100mg促销 |
≥98% | ￥1790.00 ￥1610.00 |
10 | - | - | - | - |
|
| 产品描述： | NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | JAK2 JH1:0.48 nM (IC50);FL JAK2 V617F:0.56 nM (IC50);FL JAK2 wt:0.58 nM (IC50);TYK2 JH1:10.76 nM (IC50);JAK3 JH1:18.68 nM (IC50);JAK1 JH1:31.63 nM (IC50);TyrosineKinases;JAK | ||||||||||||||||||||
| 体内研究： | NVP-BSK805 (BSK 805; 150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model. NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice | ||||||||||||||||||||
| 参考文献： | 1. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. 2. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京