FK506

98.60%

FK506

质检下载产品说明书 SDS 产品使用指南

品牌：源叶(MedMol)

产品编号：S80090 一键复制产品信息

CAS号：109581-93-3

分子式：C₄₄H₆₉NO₁₂.H₂O

分子量：822.03

别名：他克莫司一水合物;FK-506一水合物; 他克莫司水合物; 大环哌喃一水合物; [3S-[3R[E(1S,3S,4S)],4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-十六氢-5,19-二羟基-3-[2-(4-羟基-3-甲氧基环已基)-1-甲基乙烯基]-14,16-二

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80090-5mg买3赠1	98.60%	￥136.00 S80090-5mg ￥136.00 现货（买3赠1）	6 4 6	2	2	-	-
S80090-10mg买3赠1	98.60%	￥190.00 S80090-10mg ￥190.00 现货（买3赠1）	4 4	-	-	-	-
S80090-50mg买3赠1	98.60%	￥340.00 S80090-50mg ￥340.00 现货（买3赠1）	3 3	-	-	-	-
S80090-250mg	98.60%	￥496.00 S80090-250mg ￥496.00 现货	1 1	-	-	-	-

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产品介绍参考文献(2篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties

靶点：

Macrolide;Phosphatase;Antibacterial;Antibiotic;Autophagy

体内研究：

The therapeutic effect of Tacrolimus is investigated on progression and perpetuation of colitis by administering Tacrolimus to Dextran sulfate sodium (DSS)-treated mice from Days 10 to 16 or to 23. At Days 17 and 24, colon length is significantly shortened, and colon weight is significantly higher in DSS-treated control animals than in normal animals. In addition, colon weight per unit length in the control group is more than twice that in the normal group. While both 7 and 14 d treatment with Tacrolimus significantly suppresses increases in colon weight per unit length in DSS-treated animals compared with the control group, this treatment does not actually restore the colon shortening. In addition, this inhibitory effect of Tacrolimus on increases in colon weight per unit length is more pronounced with 14-d than 7-d treatment, as shown by the inhibitory percentages (59% vs. 28%)

参考文献：

1. Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. 2. Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-γ and interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7. 3. Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886. 4. Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.

溶解性：

DMSO : 100 mg/mL (121.65 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.217 ml	6.083 ml	12.165 ml
5 mM	0.243 ml	1.217 ml	2.433 ml
10 mM	0.122 ml	0.608 ml	1.217 ml
50 mM	0.024 ml	0.122 ml	0.243 ml