货号	规格	价格	上海	北京	珠海	重庆	武汉
S80101-5mg促销	≥98%	￥704.00 ￥632.00 S80101-5mg ￥632.00 现货	2 2	1	-	-	-
S80101-10mg促销	≥98%	￥1110.00 ￥1000.00 S80101-10mg ￥1000.00 现货	8 8	-	-	-	-
S80101-25mg促销	≥98%	￥2410.00 ￥2160.00 S80101-25mg ￥2160.00 现货	3 3	-	-	-	-
S80101-50mg促销	≥98%	￥4070.00 ￥3670.00 S80101-50mg ￥3670.00 现货	3 3	-	-	-	-
S80101-100mg促销	≥98%	￥6950.00 ￥6250.00 S80101-100mg ￥6250.00 现货	1 1	-	-	-	-

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产品描述：

GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM

靶点：

IC50: 2.0 nM (IGF-IR), 1.6 nM (insulin receptor), 0.5 nM (ALK);IGF-1R;JNK;S6Kinase;ALK

体内研究：

GSK1838705A shows robust antitumor activity in animal xenograft models. Tumor types likely to respond to GSK1838705A include multiple myeloma and Ewing's sarcoma, as well as ALK-driven tumors (e.g., ALCL, NSCLC, and neuroblastoma). A single oral dose of GSK1838705A at 0.1 and 0.3 mg/kg results in 35% and 65% inhibition of IGF-IR phosphorylation, respectively, whereas doses ≥1 mg/kg results in complete inhibition of ligand-induced IGF-IR phosphorylation

参考文献：

1. Sabbatini P, et al. GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.878 ml	9.388 ml	18.777 ml
5 mM	0.376 ml	1.878 ml	3.755 ml
10 mM	0.188 ml	0.939 ml	1.878 ml
50 mM	0.038 ml	0.188 ml	0.376 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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