HYDROXY ITRACONAZOLE

99.20%

HYDROXY ITRACONAZOLE

质检下载产品说明书 SDS 产品使用指南

品牌：源叶(MedMol)

产品编号：S80107 一键复制产品信息

CAS号：112559-91-8

分子式：C₃₅H₃₈Cl₂N₈O₅

分子量：721.643

别名：羟基伊曲康唑(伊曲康唑代谢物);羟基伊曲康唑;伊曲康唑2-羟基代谢物;HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-di

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S80107-1mg	99.20%	￥1420.00 S80107-1mg ￥1420.00 现货	1 0 1	-	-	-	-
S80107-5mg促销	99.20%	￥3890.00 ￥3680.00 S80107-5mg ￥3680.00 现货	1 1	-	-	-	-

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产品介绍参考文献(2篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

靶点：

Antifungal

体内研究：

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view

参考文献：

1. Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32.

溶解性：

DMSO : 100 mg/mL (138.58 mM; Need ultrasonic) H2O : 1 mg/mL (1.39 mM; ultrasonic and warming and heat to 80°C)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.386 ml	6.929 ml	13.857 ml
5 mM	0.277 ml	1.386 ml	2.771 ml
10 mM	0.139 ml	0.693 ml	1.386 ml
50 mM	0.028 ml	0.139 ml	0.277 ml