品牌：源叶(MedMol)

产品编号：S80116 一键复制产品信息

CAS号：1137608-69-5

分子式：C₃₆H₃₅ClF₃N₇O₆

分子量：754.17

别名：4-[2-氨基-6-[(1R)-1-[4-氯-2-(3-甲基-1H-吡唑-1-基)苯基]-2,2,2-三氟乙氧基]-4-嘧啶基]-L-苯丙氨酸乙酯 N-苯甲酰甘氨酸盐;Telotristat etiprate (USAN); Telotristat etiprate; (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80116-5mg买3赠1	99.83%	￥279.00 S80116-5mg ￥279.00 现货（买3赠1）	6 6	-	-	-	-
S80116-10mg促销	99.83%	￥412.00 ￥410.00 S80116-10mg ￥410.00 现货	7 7	-	-	-	-
S80116-50mg买3赠1	99.83%	￥1330.00 S80116-50mg ￥1330.00 现货（买3赠1）	6 0 6	-	-	-	-
S80116-250mg买3赠1	99.83%	￥3700.00 S80116-250mg ￥3700.00 现货（买3赠1）	4 0 4	-	-	-	-
S80116-1g	99.83%	￥9260.00 S80116-1g ￥9260.00 现货	3 0 3	-	-	-	-

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产品描述：

Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

靶点：

Tryptophan Hydroxylase;Hydroxylase

体内研究：

Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis

参考文献：

1. Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model. 2. Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

溶解性：

Soluble in DMSO

保存条件：

避光;-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.326 ml	6.63 ml	13.26 ml
5 mM	0.265 ml	1.326 ml	2.652 ml
10 mM	0.133 ml	0.663 ml	1.326 ml
50 mM	0.027 ml	0.133 ml	0.265 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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