| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80121-2mg促销 |
≥98% | ￥510.00 ￥408.00 |
货期：2-3天 | - | - | - | - |
|
S80121-5mg促销 |
99.70% | ￥710.00 ￥639.00 |
4 | - | - | - | - |
|
S80121-10mg |
≥98% | ￥1230.00 |
货期：2-3天 | - | - | - | - |
|
S80121-25mg |
≥98% | ￥2580.00 |
货期：2-3天 | - | - | - | - |
|
S80121-50mg |
≥98% | ￥4120.00 |
货期：2-3天 | - | - | - | - |
|
S80121-100mg |
≥98% | ￥6390.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | mTORC1;mTORC2;mTOR:0.19 nM (IC50);PI3Kα:1.179 μM (IC50);PI3Kδ:2.38 μM (IC50);hSMG1:1.25 μM (IC50);Apoptosis;mTOR | ||||||||||||||||||||
| 体内研究： | A single i.v. administration of 50 mg/kg WYE-132 (WYE-125132) into tumor-bearing mice leads to suppression of P-S6K(T389) and P-AKT(S473) for at least 8 hours in PC3MM2, MDA361, HCT116, and HT29 tumors, whereas the steady-state level of P-AKT(T308) is not significantly reduced, indicating that the antitumor efficacy of WYE-132 under such dosing regimens reflects the suppression of mTOR rather than PI3K. Oral administration of WYE-132 causes dose-dependent tumor growth delay in the PI3K/mTOR- and HER2-hyperactive MDA361 tumors with significant antitumor activity at 5 mg/kg, which correlates with a suppression P-S6 and P-AKT(S473) but not P-AKT(T308). An optimal dose of 50 mg/kg WYE-132 induces a substantial regression of large MDA361 tumors. WYE-132 also causes a potent and substantial tumor growth delay in the PTEN-null U87MG glioma | ||||||||||||||||||||
| 参考文献： | 1. Yu K, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res. 2010 Jan 15;70(2):621-631. | ||||||||||||||||||||
| 溶解性： | DMSO : 25 mg/mL (48.11 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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